中国组织工程研究

中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (46): 7427-7431.doi: 10.3969/j.issn.2095-4344.2014.46.010

• 皮肤粘膜组织构建 skin and mucosal tissue construction • 上一篇    下一篇

内剥切并局部注射治疗耳郭瘢痕疙瘩

唐 洁，李小静，唐悦玲，宁金龙   

  1. 安徽医科大学第一附属医院整形外科，安徽省合肥市 230022
  • 修回日期:2014-10-31 出版日期:2014-11-12 发布日期:2014-11-12
  • 通讯作者: 李小静，硕士，主任医师，教授，硕士生导师，安徽医科大学第一附属医院整形外科，安徽省合肥市 230022
  • 作者简介:唐洁，女，1979年生，安徽省淮南市人，汉族，在职硕士，医师，主要从事瘢痕防治研究。
  • 基金资助:

    安徽省自然科学基金(11040606M202)；国家自然科学基金(81272107)

Application of striping and local injections in patients with auricle keloid  

Tang Jie, Li Xiao-jing, Tang Yue-ling, Ning Jin-long   

  1. Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
  • Revised:2014-10-31 Online:2014-11-12 Published:2014-11-12
  • Contact: Li Xiao-jing, Master, Chief physician, Professor, Master’s supervisor, Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
  • About author:Tang Jie, Studying for master’s degree, Physician, Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
  • Supported by:

    the Natural Science Foundation of Anhui Province, No. 11040606M202; the National Natural Science Foundation of China, No. 81272107

PDF

599

被引次数

2

摘要：

背景：瘢痕疙瘩是创伤后皮肤异常修复的结果，表现为过度生长且进行性增大、侵犯邻近正常皮肤组织、常扩展到原伤口范围以外，单纯手术切除后极易复发，故需结合其他方法进行综合治疗。

目的：探讨耳郭瘢痕疙瘩内核剥除术后及时局部注射的临床疗效。
方法：20例耳郭瘢痕疙瘩患者，采用瘢痕疙瘩核心摘除术，并分别于术后逐渐拉长间隔时间，于切口瘢痕组织内注射氟尿嘧啶或曲安奈德加利多卡因混合或单独用药，必要时按瘢痕情况偶加用适量的复方倍他米松，视瘢痕的消退情况及时调节药物的注射剂量，观察治疗12个月到24个月。
结果与结论：20例患者36个耳部瘢痕，其中有1个耳部瘢痕为效果有效，35个为耳部瘢痕为治愈。随访12-24个月，均无复发，有效率为100%，其中完全治愈者97%，效果良好者3%。结果表明，瘢痕疙瘩核心切除并利用其上皮瓣覆盖整形，联合氟尿嘧啶与糖皮质激素局部注射治疗耳郭瘢痕疙瘩是安全有效的方法。


中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

关键词: 组织构建, 组织工程, 瘢痕疙瘩, 内剥切, 瘢痕皮回植, 曲安奈德, 5-氟尿嘧啶, 国家自然科学基金

Abstract:

BACKGROUND: Keloids are the result of abnormal post-traumatic skin restoration, which are characterized with overgrowth and progressive enlargement, invasion of adjacent normal skin tissue, extension beyond the scope of the original wound. Given the high recurrence, treatment with surgery alone is meaningless and, therefore, comprehensive treatment of surgery and other approaches is required.

OBJECTIVE: To explore the clinical curative effect of local injection after timely removal of auricle keloid core.
METHODS: Twenty patients with auricle keloid were enrolled. After keloid core excision, the time interval within the incision scar tissue injection of fluorouracil or triamcinolone acetonide add lidocaine or monotherapy was gradually lengthened, and if necessary the proper amount of compound betamethasone was added according to scar conditions. The injection dose was adjusted timely based on the regression of scar. The treatment effect was observed for 12 to 24 months.
RESULTS AND CONCLUSION: Of 36 auricle keloids from 20 patients, the comprehensive treatment was effective in 1 keloid, and other 35 keloids were cured. The effective rate was 100%, the completely cured rate was 97.2% and the excellent rate was 2.8%. These findings indicate that minimally invasive excision of keloid core and the epithelial flap coverage combined with 5-fluorouracil and corticosteroid injection is a safe and effective method to treat auricle keloids.


中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


全文链接：

Key words: keloid, triamcinolone acetonide, fluorouracil

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